About Us
The Mowery Lab utilizes genetically engineered mouse models, patient-derived samples and molecular biology techniques to study head and neck cancer development and progression, as well as the interplay between radiation therapy and the immune system and head and neck cancer. We have a particular interest in understanding the molecular underpinnings of radiation resistance in head and neck squamous cell carcinoma and immune dysregulation in the tumor microenvironment. Our overarching goal is to translate scientific discoveries from the bench to the bedside to advance the care and improve the quality of life for patients with cancer.
Recent Work
Mowery lab published “Preclinical Evaluation of the ATR Inhibitor BAY 1895344 as a Radiosensitizer for Head and Neck Squamous Cell Carcinoma” in the International Journal of Radiation Oncology*Biology*Physics.
These preclinical data supported the initiation of a multi-institutional phase I clinical trial evaluating the safety and efficacy of BAY 1895344 with radiation therapy and pembrolizumab in patients with recurrent, previously irradiated head and neck cancer.